At closing time on the New York Stock Exchange, the Dow Jones was down 0.24%, the S&P 500 was down 0.41% and the NASDAQ Composite was down 0.89%.

The leaders among Dow Jones index components in today's trading were shares of JPMorgan Chase & Co. which gained 2.28p (1.81%) to close at 128.16. Nike Inc rose 1.09 pct (1.18%) to close at 93.77. Goldman Sachs Group Inc rose 3.94p (1.14%) to close at 348.45.

The least gainers were shares of Apple Inc, which fell 2.69p (1.75%) to close the session at 150.65. Salesforce Inc shares rose 2.79p (1.72%) to close at 159.80, while Microsoft Corporation dropped 3.96p (1.71%) to close at 228.17.

The top gainers among S&P 500 index components in today's trading were ABIOMED Inc which gained 49.88% to 377.82, IDEXX Laboratories Inc which gained 9.80% to close at 394.93, and Hologic Inc which gained 9.34% to end the session at 74.13.

Catalent Inc shares were the fallers, down 24.62% to close at 49.55. Shares of Zebra Technologies Corporation lost 15.86% and ended the session at 238.30. Ecolab Inc dropped 8.98% to 142.96.

The gainers among the components of the NASDAQ Composite index in today's trading were shares of ABIOMED Inc. which gained 49.88% to 377.82, Sonnet Biotherapeutics Holdings Inc. which gained 46.63% to close at 2.83 and shares of NLS Pharmaceutics AG which gained 44.00% to close the session at 0.74.

Varonis Systems shares were the fallers, dropping 35.49% to close at 17.27. Shares of China Liberal Education Holdings lost 27.39% to end the session at 1.14. Acorda Therapeutics Inc. was down 25.22% to 0.80.

On the NYSE, 1,960 securities gained more than 1,172 which closed negative and 95 were flat. On NASDAQ, 2,101 stocks gained in value, 1,680 declined, and 194 remained flat.

The CBOE Volatility Index, which is based on the S&P 500 options trade, fell 0.27% to 25.81.

Gold futures for December delivery added 0.55%, or 8.95, to $1.00 per troy ounce. In other commodities, December WTI crude oil futures rose 2.02%, or 1.75, to $88.28 a barrel. January Brent crude futures traded up 1.83%, or 1.70, to $94.51 per barrel.

Meanwhile, on the Forex market, EUR/USD remained unchanged 0.08% to 0.99, while USD/JPY dropped 0.33% to 148.23.

The USD index futures rose 0.02% to 111.44.